The purpose of this project is to utilize the case-control, interview methodology to do in-depth evaluations of specific cancer sites. By the nature of this method, the exposures evaluated include many of the exposure categories under which other Branch studies are listed; however, either because there are numerous etiologic hypotheses to be tested, or because a tumor deserves an in-depth evaluation in an attempt to generate hypotheses, these types of studies cover a number of different exposure categories, and are therefore considered a separate program area.